- Inhibition of parathyroid hormone release
- Suppression of PTH production
- Increase in serum calcium levels
- Alfacalcidol is an activated form of cholecalciferol (Vitamin D). Capsules: 0.25 micrograms, 0.5 micrograms, 1 microgram
- Oral drops: 2 micrograms/ml (1 drop contains approximately 0.1 microgram). Injection: 2 micrograms/ml
- Hypercalcaemia, metatastic calcification
- Monitor calcium closely. Symptoms of hypercalcaemia include: metallic taste, headache, nausea, weakness, polyuria, polydipsia, constipation, dry mouth, muscle and bone pain
- Watch for arrhythmias if used with digoxin
Note: red eyes may indicate hypercalcaemia
- Pruritus, rash
- 0.25-1 micrograms daily adjusted to serum calcium level
- Higher doses may be required post parathyroidectomy to maintain calcium levels in the normal range
- Dose as in normal renal function
- May be given three times a week to minimise effect on serum calcium; and for patients on thrice weekly haemodialysis to aid adherence
- Larger doses may required if given in combination with carbamazepine, phenytoin or primidone
ALFACALCIDOL#0.25 micrograms#see prescribing section#PO#8
- Alfacalcidol is a form of vitamin D
- If you develop a rash, try moisturisers to soothe the rash. If severe, see your doctor
- If you experience loss of appetite, weakness or red eyes, see your doctor
- Alfacacidol capsules contain gelatine. Oral drops must be stored in the fridge
