Iron (IV)

• Treatment or prophylaxis of iron deficiency anaemia

• Venofer® iron sucrose; 100 mg/5ml
• Cosmofer® iron dextran; 100 mg/2ml, 500 mg/10ml
• Ferrinject® ferric carboxymaltose; 100 mg/2ml, 500 mg/10ml
• Monofer® iron(III) isomaltoside 1000; 100 mg/ml
• Rienso® ferumoxytol 30 mg/ml
• Prescribe by brand

• Iron overload, anaemia not caused by iron deficiency
• Hypersensitivity to iron or to any of the excipients
• Pregnancy first trimester

• Monitor iron stores. Aim for a ferritin 100-500 ng/ml and TSAT >20%
• Anaphylactic reactions can occur with all preparations. A test dose is recommended before the first dose; and before each dose with Iron Dextran. Care in asthmatic patients
• Parenteral iron must be used with caution in cases of acute or chronic infection. It is recommended that the administration of IV iron is stopped in patients with on-going bacteraemia

• Metallic taste, hypotension, fever and shivering, allergic reactions

• A test dose is required before the first dose
• Patients on HD: varies from 20 mg each dialysis to 100 mg weekly, fortnightly or monthly
• Patients not on HD: varies between centres. Examples include 100 mg fortnightly for 3 doses or 1g as a total dose infusion

• As in normal renal function, not dialysed

• Reduced absorption of oral iron, dimercaprol – avoid concomitant use

VENOFER#100 mg#see prescribing section#IV#

• Preparation used and dose given varies according to local protocols