Alfacalcidol (1αhydroxycholecalciferol)

• Inhibition of parathyroid hormone release
• Suppression of PTH production
• Increase in serum calcium levels

• Alfacalcidol is an activated form of cholecalciferol (Vitamin D). Capsules: 0.25 micrograms, 0.5 micrograms, 1 microgram
• Oral drops: 2 micrograms/ml (1 drop contains approximately 0.1 microgram). Injection: 2 micrograms/ml

• Hypercalcaemia, metatastic calcification

• Monitor calcium closely. Symptoms of hypercalcaemia include: metallic taste, headache, nausea, weakness, polyuria, polydipsia, constipation, dry mouth, muscle and bone pain
• Watch for arrhythmias if used with digoxin

Note: red eyes may indicate hypercalcaemia

• Pruritus, rash

• 0.25-1 micrograms daily adjusted to serum calcium level
• Higher doses may be required post parathyroidectomy to maintain calcium levels in the normal range

• Dose as in normal renal function
• May be given three times a week to minimise effect on serum calcium; and for patients on thrice weekly haemodialysis to aid adherence

• Larger doses may required if given in combination with carbamazepine, phenytoin or primidone

• Alfacalcidol is a form of vitamin D
• If you develop a rash, try moisturisers to soothe the rash. If severe, see your doctor
• If you experience loss of appetite, weakness or red eyes, see your doctor
• Alfacacidol capsules contain gelatine. Oral drops must be stored in the fridge